ACTL6B Polyclonal Antibody

Background:
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Stem cells

Synonyms:
53 kDa BRG1 associated factor B, 53 kDa BRG1-associated factor B, ACL 6B, ACL6B, ACL6B, Actin like 6, Actin like protein 6B, Actin like protein6B, Actin related protein, Actin related protein Baf53b, actin-like 6B, Actin-like protein 6B, Actin-related protein Baf53b, Actl 6, ACTL 6B, Actl6, ACTL6 B, Actl6b, Arp Na, ArpN a, ArpN alpha, ArpNa, ArpNalpha, Baf 53b, BAF53B, BRG1-associated factor 53B

Immunogen: Fusion protein of human ACTL6B

Swissprot: O94805
Gene Accession: BC020944

Calculated MW: 47 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.74 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.