ACTL7B antibody (clone 6A4), anti-human
€435.00
In stock
SKU
AC-AT1031a
Catalog Number: AC-AT1031a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
Request Information AC-AT1031a">Request Information
Background:
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.
Other Names:
Actin-like protein 7B, Actin-like-7-beta, ACTL7B
Antigen Type:
Recombinant Protein
Gene Name: ACTL7B
Gene ID: 10880
NCBI Accession: NP_006677.1
Primary Accession: Q9Y614
Other Accession: NM_006686
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.
Other Names:
Actin-like protein 7B, Actin-like-7-beta, ACTL7B
Antigen Type:
Recombinant Protein
Gene Name: ACTL7B
Gene ID: 10880
NCBI Accession: NP_006677.1
Primary Accession: Q9Y614
Other Accession: NM_006686
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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