ACTN1 antibody (clone 3F1), anti-human
€435.00
In stock
SKU
AC-AT1032a
Catalog Number: AC-AT1032a
Size: 100 µg
Isotype: mouse IgG3 Kappa
Applications: WB
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Size: 100 µg
Isotype: mouse IgG3 Kappa
Applications: WB
Request Information AC-AT1032a">Request Information
Background:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
Other Names:
Alpha-actinin-1, Alpha-actinin cytoskeletal isoform, F-actin cross-linking protein, Non-muscle alpha-actinin-1, ACTN1
Antigen Type:
Recombinant Protein
Gene Name: ACTN1
Gene ID: 87
NCBI Accession: NP_001093.1;NP_001123476.1;NP_001123477.1
Primary Accession: P12814
Other Accession: NM_001102
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
Other Names:
Alpha-actinin-1, Alpha-actinin cytoskeletal isoform, F-actin cross-linking protein, Non-muscle alpha-actinin-1, ACTN1
Antigen Type:
Recombinant Protein
Gene Name: ACTN1
Gene ID: 87
NCBI Accession: NP_001093.1;NP_001123476.1;NP_001123477.1
Primary Accession: P12814
Other Accession: NM_001102
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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