ACTN1 polyclonal antibody, anti-human, mouse, rat

Background:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins| including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells| the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions| where it is involved in binding actin to the membrane. In contrast| skeletal| cardiac| and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies| where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle| cytoskeletal| alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Research Area: Developmental biology, Signal transduction, Stem cells

Synonyms: Alpha-actinin-1 , Alpha-actinin cytoskeletal isoform, F-actin cross-linking protein, Non-muscle alpha-actinin-1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year