ACTN4 antibody (clone 4D10), anti-human, mouse, rat
€435.00
In stock
SKU
AC-AT1033a
Catalog Number: AC-AT1033a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF, E
Request Information AC-AT1033a">Request Information
Background:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Other Names:
Alpha-actinin-4, F-actin cross-linking protein, Non-muscle alpha-actinin 4, ACTN4
Antigen Type:
Recombinant Protein
Gene Name: ACTN4 (HGNC:166)
Gene ID: 81
NCBI Accession: NP_004915.2
Primary Accession: O43707
Other Accession: NM_004924
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Other Names:
Alpha-actinin-4, F-actin cross-linking protein, Non-muscle alpha-actinin 4, ACTN4
Antigen Type:
Recombinant Protein
Gene Name: ACTN4 (HGNC:166)
Gene ID: 81
NCBI Accession: NP_004915.2
Primary Accession: O43707
Other Accession: NM_004924
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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