ACVR2A polyclonal, anti-human, mouse, rat

Background:
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Synonyms: ACTRII, ACVR2

Cellular Location: Membrane Single-pass type I membrane protein

Immunogen:
Recombinant protein of human ACVR2A

Gene Symbol: ACVR2A

Gene ID: 92

Swiss prot: P27037

Calculated MW: 58kDa

Recommended dilution:
WB 1:500-2000, IHC 1:100-200, IF 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.