ACVR2A Polyclonal Antibody

Background:
This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

Research Area: Cancer, Metabolism, Signal Transduction, Stem Cells

Synonyms:
Activin A receptor type IIA, Activin receptor type 2A, Activin receptor type IIA, Activin receptor type-2A, ACTR 2, ACTR IIA, ACTR-IIA, ACTR2, ACTRII, ACTRIIA, Acvr 2, Acvr 2A, Acvr2, ACVR2A, AVR2A, OTTHUMP00000197918

Immunogen: Synthetic peptide of human ACVR2A

Swissprot: P27037
Gene Accession: NP_001607

Calculated MW: 58 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 1.2 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-5669/sc-130679/sc-25451

Citation(s):
https://pubmed.ncbi.nlm.nih.gov/29193906/