ADAM 15 polyclonal, anti-human

Protein Family: Enzymes, Peptidases, CAM Ligands

Pathway and Disease: Signaling Molecules and Interaction, Cell Motility, Immune System

Description:
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) is a metalloproteinase with gelatinolytic and collagenolytic activity. ADAM 15 plays a role in the wound healing process, mediating both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. ADAM 15 inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. ADAM 15 suppresses cell motility towards fibronectin by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. ADAM 15 cleaves E-cadherin in response to growth factor deprivation.

Alternate Names: Disintegrin and metalloproteinase domain-containing protein 15, ADAM 15, Metalloproteinase-like, distegrin-like, and cysteine-rich protein 15, MDC-15, Metalloprotease RGD disintegrin protein, Metargidin, ADAM15, MDC15

Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:1,000; IHC: 1:100-1:500

Accession No.: Q13444

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ADAM 15.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.