ADAM 33 polyclonal, anti-human
€422.00
In stock
SKU
252001
Protein Family: Enzymes, Peptidases
Pathway and Disease: Signaling Molecules and Interaction
Description:
Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) is a single-pass type I membrane protein expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting ADAM 33. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates ADAM 33. Genetic variations in ADAM33 are associated with susceptibility to asthma, the most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
Alternate Names: Disintegrin and metalloproteinase domain-containing protein 33, ADAM 33, ADAM33, C20orf153
Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:1,000
Accession No.: Q9BZ11
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ADAM 33.
Format: Each vial contains 0.1 mL of crude serum with 0.09% sodium azide.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) is a single-pass type I membrane protein expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting ADAM 33. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates ADAM 33. Genetic variations in ADAM33 are associated with susceptibility to asthma, the most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
Alternate Names: Disintegrin and metalloproteinase domain-containing protein 33, ADAM 33, ADAM33, C20orf153
Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:1,000
Accession No.: Q9BZ11
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ADAM 33.
Format: Each vial contains 0.1 mL of crude serum with 0.09% sodium azide.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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