ADAM-TS2 polyclonal, anti-human

Protein Family: Enzymes, Peptidases

Pathway and Disease: Cell Growth and Death

Description:
A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) cleaves the propeptides of type I and II collagen prior to fibril assembly. ADAM-TS2 does not act on type III collagen. ADAM-TS2 also plays a role in development that is independent of its role in collagen biosynthesis. ADAM-TS2 cleaves the N-propeptide of collagen chain alpha-1(I) at Pro-|-Gln and of alpha-1(II) and alpha-2(I) at Ala-|-Gln. It is expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity.

Alternate Names: A distintegrin and metalloproteinase with thrombospondin motifs 2, ADAMTS-2, ADAM-TS 2, ADAM-TS2, Procollagen I/II amino propeptide-processing enzyme, Procollagen I N-proteinase, PC I-NP, Procollagen N-endopeptidase, pNPI, ADAMTS2, PCINP, PCPNI

Application Notes: E: 1:1,000-1:10,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: O95450

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human ADAM-TS2 protein.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5 % BSA with 0.09% sodium azide. Antibody was purified by immunogen-affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.