ADAM17 Functional (blocking) recombinant mAb (clone D1(A12)), preservative free, anti-human
€445.00
In stock
SKU
AC-ADP0048-U0100
Catalog Number: AC-ADP0048-U0100
Size: 100 µg
Isotype:
Size: 100 µg
Isotype:
Background:
ADAM17 (Disintegrin and metalloproteinase domain-containing protein 17), also called TACE (Tumor necrosis factor-α-converting enzyme) is the prototype of the ADAM family of ectodomain shedding proteases (sheddase). ADAM17 is understood to be involved in the processing of TNF-α at the surface of the cell and from within the intracellular membranes of the trans-Golgi network. This process involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-α) and is of known physiological importance. ADAM17 is responsible for the processing of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands and enzymes, including cleaving epidermal growth factor receptor (EGFR) ligands and extracellular Notch1. The proteolytic cleavage is an indispensable activation event for many of these substrates, ADAM17 has emerged as an attractive therapeutic target for the treatment of inflammatory diseases (e.g. rheumatoid arthritis) or inflammation associated cancer.
Other Names:
TNF-α-converting Enzyme; Disintegrin and Metalloproteinase Domain-containing Protein 17; CD156b
Gene Name: ADAM17 (HGNC:195)
Gene ID: 6868
Primary Accession: P78536
ADAM17 (Disintegrin and metalloproteinase domain-containing protein 17), also called TACE (Tumor necrosis factor-α-converting enzyme) is the prototype of the ADAM family of ectodomain shedding proteases (sheddase). ADAM17 is understood to be involved in the processing of TNF-α at the surface of the cell and from within the intracellular membranes of the trans-Golgi network. This process involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-α) and is of known physiological importance. ADAM17 is responsible for the processing of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands and enzymes, including cleaving epidermal growth factor receptor (EGFR) ligands and extracellular Notch1. The proteolytic cleavage is an indispensable activation event for many of these substrates, ADAM17 has emerged as an attractive therapeutic target for the treatment of inflammatory diseases (e.g. rheumatoid arthritis) or inflammation associated cancer.
Other Names:
TNF-α-converting Enzyme; Disintegrin and Metalloproteinase Domain-containing Protein 17; CD156b
Gene Name: ADAM17 (HGNC:195)
Gene ID: 6868
Primary Accession: P78536
| Is Featured? | No |
|---|
Write Your Own Review