ADAM17 polyclonal, anti-human, mouse, rat

Background:
Tumor necrosis factor β (TNFβ), also known as lymphotoxin, is a pleiotropic cytokine. TNFα, also known as cachetin, is a cytokine that binds to the same receptors, producing an array of effects similar to those of TNFβ. TNFβ and TNFα share 30% amino acid homology and have similar biological activities. TNFβ is produced by activated lymphocytes, including CD4+ T helper cell type 1 lymphocytes, CD8+ lymphocytes and certain B lymphoblastoid cell lines. TNFα is produced by several different cell types, including lymphocytes, neutrophils and macrophages. TNFβ and TNFα can modulate many immune and inflammatory functions while having the ability to inhibit tumor growth. TACE (for TNFα converting enzyme) is a metalloproteinase that cleaves the membrane-bound TNFα precursor to release soluble TNFα.

Alternative Name:
ADAM 17, A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), A disintegrin and metalloproteinase domain 17, ADA17, ADAM 17, ADAM metallopeptidase domain 17, ADAM17, ADAM17 protein, CD 156b, CD156b, CD156b antigen, CSVP, Disintegrin and metalloproteinase domain-containing protein 17, MGC71942, NISBD, NISBD1, Snake venom like protease, Snake venom-like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme, TNF-alpha convertase, TNF-alpha-converting enzyme, Tumor Necrosis Factor Alpha Converting Enzyme,

Application Dilution:
WB:1:1,000-1:2,000
FC:1:50-1:100
ICC:1:50-1:200
IP:1:50

Specificity: ADAM17 polyclonal antibody detects endogenous levels of ADAM17 protein.

Immunogen:
recombinant protein

MW: 93 kDa

Swiss-Prot: P78536(Human) Q9Z0F8(Mouse) Q9Z1K9(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.