ADAMTS1 polyclonal, anti-rat, mouse

Quantity: 100 µg

Background:
ADAMTS1(A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif, 1), also known as METH1, is an enzyme that in humans is encoded by the ADAMTS1 gene. ADAMTS is a family of proteins believed to be anchored to the extracellular matrix(ECM) through interactions with aggregan or other matrix components by one or more thrombospondin type 1 motifs. Scott(2000) mapped the ADAMTS1 gene to 21q21.2 based on sequence similarity between the ADAMTS1 sequence and a chromosome 21q21.2 clone. Kuno et al.(1997) found that mouse Adamts1 expression could be induced in vitro in colon adenocarcinoma cells by stimulation with the inflammatory cytokine interleukin 1-alpha, or in vivo in kidney and heart by intravenous administration of lipopolysaccharide. Vazquez et al.(1999) determined that ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, THBS1, or endostatin.

Description:
Rabbit IgG polyclonal antibody for A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) detection. Tested with WB in Mouse, Rat.

Synonyms:
A disintegrin and metalloproteinase with thrombospondin motifs 1 antibody, A disintegrin like and metalloprotease with thrombospondin type 1 motif 1 antibody, A disintegrin-like and metalloprotease(reprolysin type) with thrombospondin type 1 motif 1 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 1 antibody, ADAM TS 1 antibody, ADAM TS1 antibody, ADAM-TS 1 antibody, ADAM-TS1 antibody, ADAMTS 1 antibody, ADAMTS antibody, ADAMTS-1 antibody, Adamts1 antibody, ATS1_HUMAN antibody, C3 C5 antibody, KIAA1346 antibody, KIAA1346, antibody, METH 1 antibody, METH-1 antibody, METH1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of mouse ADAMTS1(956-968aa KHYIDFCTLTQCS), different from the related rat sequence by one amino acid, and from the related human sequence by four amino acids.A synthetic peptide corresponding to a sequence at the C-terminus of mouse ADAMTS1(956-968aa KHYIDFCTLTQCS), different from the related rat sequence by one amino acid, and from the related human sequence by four amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: rat.
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.