ADAMTS13 antibody (clone 4F12), anti-human
€435.00
In stock
SKU
AC-AT1047a
Catalog Number: AC-AT1047a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: E
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Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: E
Request Information AC-AT1047a">Request Information
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
Other Names:
A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8
Antigen Type:
Recombinant Protein
Gene Name: ADAMTS13
Gene ID: 11093
NCBI Accession: NP_620594.1;NP_620595.1;NP_620596.2
Primary Accession: Q76LX8
Other Accession: NM_139025
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
Other Names:
A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8
Antigen Type:
Recombinant Protein
Gene Name: ADAMTS13
Gene ID: 11093
NCBI Accession: NP_620594.1;NP_620595.1;NP_620596.2
Primary Accession: Q76LX8
Other Accession: NM_139025
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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