ADAMTS2 Polyclonal Antibody

Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cell Biology, Cardiovascular, Signal Transduction

Synonyms:
A disintegrin and metalloproteinase with thrombospondin motifs 2, A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2, ADAM metallopeptidase with thrombospondin type 1 motif 2, ADAM TS 2, ADAM TS2, ADAM-TS 2, ADAM-TS2, ADAMTS 3, ADAMTS-2, ADAMTS2, ATS2, EC 3.4.24.14, EDS VIIB, EDS VIIC, hPCPNI, NPI, PC I NP, PC I-NP, PCINP, PCPNI, pNPI, Procollagen I N proteinase, Procollagen I N-proteinase, Procollagen I/II amino propeptide processing enzyme, Procollagen I/II amino propeptide-processing enzyme, Procollagen N endopeptidase, Procollagen N-endopeptidase

Immunogen: Synthetic peptide of human ADAMTS2

Swissprot: O95450
Gene Accession: NP055059

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.