ADAMTS4 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene. ADAMTS4 is a member of the large ADAMTS family of zinc-dependent proteases. The human ADAMTS4 gene is mapped to chromosome 1 by somatic cell hybrid analysis. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Description:
Rabbit IgG polyclonal antibody for A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody, A disintegrin like and metalloprotease(reprolysin type) with thrombospondin type 1 motif 4 antibody, A disintegrin like and metalloprotease with thrombospondin type 1 motif 4 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 4 antibody, ADAM TS 4 antibody, ADAM TS4 antibody, ADAM-TS 4 antibody, ADAM-TS4 antibody, ADAMTS 2 antibody, ADAMTS 4 antibody, ADAMTS-4 antibody, ADAMTS2 antibody, ADAMTS4 antibody, ADAMTS4 protein antibody, ADMP 1 antibody, ADMP-1 antibody, ADMP1 antibody, Aggrecanase 1 antibody, Aggrecanase-1 antibody, Aggrecanase1 antibody, ATS4_HUMAN antibody, KIAA0688 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human ADAMTS4(820-837aa RRAQILEILRRRPWAGRK), different from the related rat and mouse sequences by three amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.