ADAMTS4 polyclonal (C-term), anti-human, mouse

Background:
ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Other Names:
A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688

Target/Specificity:
This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 705-736 amino acids from the C-terminal region of human ADAMTS4.

Antigen Region:
705-736

Antigen Type: Synthetic Peptide

Gene Name: ADAMTS4
Gene ID: 9507
Primary Accession: O75173
NCBI Accession: NP_005090.3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.