ADAMTS5 polyclonal, anti-human, mouse

Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.

Synonyms: ADMP-2, ADAM-TS5, ADAMTS-5, ADAMTS11, ADAM-TS 5, ADAMTS-11, ADAM-TS 11

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human ADAMTS5

Gene Symbol: ADAMTS5

Gene ID: 11096

Swiss prot: Q9UNA0

Calculated MW: 102kDa

Recommended dilution:
WB 1:200-1000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.