ADAMTS5 Polyclonal Antibody

Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

Research Area: Cancer, Cell Biology, Signal Transduction

Synonyms:
A disintegrin and metalloproteinase with thrombospondin motifs 11, A disintegrin and metalloproteinase with thrombospondin motifs 5, A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5, A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase 2), A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 5, A Disintigrin And Metalloproteinase with ThromboSpondin motif-5, ADAM metallopeptidase with thrombospondin type 1 motif 5, ADAM TS 11, ADAM TS 5, ADAM TS5, ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS 11, ADAMTS 5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADAMTS11, formerly, Adamts5, ADMP 2, ADMP-2, ADMP2, Aggrecanase 2, Aggrecanase-2, ATS5, FLJ36738, Implantin, ThromboSpondin motif-5

Immunogen: Synthetic peptide of human ADAMTS5

Swissprot: Q9UNA0
Gene Accession: NP_008969

Calculated MW: 102 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-83186/sc-134952

Citation(s):
https://pubmed.ncbi.nlm.nih.gov/32151961/