Casein Kinase Iγ2 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP68832
Catalog Number: AC-AP50964
Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, E
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, E
Datasheet
Request Information
Background:
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Other Names:
CSNK1G2; CK1G2; Casein kinase I isoform gamma-2; CKI-gamma 2
Antigen Type: synthetic peptide
Antigen Type: CSNK1G2
Gene ID: 1455
Primary Accession: P78368
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Other Names:
CSNK1G2; CK1G2; Casein kinase I isoform gamma-2; CKI-gamma 2
Antigen Type: synthetic peptide
Antigen Type: CSNK1G2
Gene ID: 1455
Primary Accession: P78368
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