ADH1A polyclonal, anti-human, mouse, rat

Background:
The alcohol dehydrogenase family of proteins metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha (ADH1A), beta (ADH1B) and gamma (ADH1C) subunits are tandemly organized on chromosome 4q22 as a gene cluster. The alpha form of ADH is monomorphic and predominant in fetal and infant livers, becoming less active in gestation and only weakly active during adulthood. The genes encoding beta and gamma subunits, however, are polymorphic and strongly expressed in adult livers. With the coenzyme NAD, ADH catalyzes the reversible conversion of organic alcohols to ketones or aldehydes. The physiologic function for ADH in the liver is the removal of ethanol formed by microorganisms in the intestinal tract.

Alternative Name:
ADH1A, ADH1, ADH alpha subunit, ADH, ADH1, ADH1A, ADH1A, Alcohol dehydrogenase 1 (class I), alpha polypeptide, Alcohol dehydrogenase 1, Alcohol dehydrogenase 1A (class I), alpha polypeptide, Alcohol dehydrogenase 1A, Alcohol dehydrogenase subunit alpha, Aldehyde reductase,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:100
IHC:1:50-1:200

Specificity: ADH1A polyclonal antibody detects endogenous levels of ADH1A protein.

Immunogen:
Recombinant protein within human Alcohol Dehydrogenase aa 1-200.

MW: 40 kDa

Swiss-Prot: P07327(Human) P00329(Mouse) P06757(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.