ADIPOR1 polyclonal, anti-human, mouse, rat, zebrafish

Background:
Adiponectin is a circulating hormone secreted by adipocytes that improves the metabolism of glucose and lipids, and is expressed at low levels in those with obesity and diabetes. Adiponectin receptors AdipoR1 and AdipoR2, also designated progestin and adipoQ receptor family members I and II, respectively, regulate fatty acid oxidation and the uptake of glucose by adiponectin. Each receptor activates a unique set of signaling molecules including AMPK, p38 MAPK and PPARα. AdipoR1 has a high-affinity for globular adiponectin and low-affinity for full-length adiponectin, while AdipoR2 has an intermediate affinity for both forms. AdipoR1 and AdipoR2 are mainly expressed in liver and muscle. Adiponectin, AdipoR1 and AdipoR2 are all associated with body composition, Insulin sensitivity, and metabolic parameters. Physical training increases circulating adiponectin and mRNA expression of AdipoR1 and AdipoR2 in muscle, which may mediate the improvement of Insulin resistance and the metabolic syndrome in response to exercise.

Alternative Name:
ADIPOR1, ACDCR1, ADIPO R1, Adiponectin receptor protein 1, ADIPOR 1, Adipor1, ADR1, CGI 45, CGI 45 protein, CGI-45, CGI45, CGI45 protein, FLJ25385, FLJ42464, PAQR1, Progestin and adipoQ receptor family member I, TESBP1A,

Application Dilution:
WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: ADIPOR1 polyclonal antibody detects endogenous levels of ADIPOR1 protein.

Immunogen:
recombinant protein

MW: 43 kDa

Swiss-Prot: Q96A54(Human) Q91VH1(Mouse) Unigene:104556(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.