ADSL polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene.

Synonyms: AMPS, ASASE, ASL

Cellular Location: Cytosol

Immunogen:
Recombinant protein of human ADSL

Gene Symbol: ADSL

Gene ID: 158

Swiss prot: P30566

Calculated MW: 55kDa

Recommended dilution:
WB 1:500-2000, IF 1:20-100, IP 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.