ADSL Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
ADSL, AMPS, ASASE, ASL

Immunogen: Recombinant fusion protein of human ADSL (NP_000017.1).

Swissprot: P30566
Gene ID: 158

Calculated MW: 48 kDa/54 kDa
Observed MW: 55 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:20-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.