AF-10 rabbit polyclonal, anti-human, mouse

Backgroud: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10(MLLT10) Homo sapiens This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010],disease:A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein.,disease:A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 2 PHD-type zinc fingers.,tissue specificity:Expressed abundantly in testis.,

Synonyms: MLLT10, AF10, Protein AF-10, ALL1-fused gene from chromosome 10 protein

Gene Name: MLLT10

Gene ID: 8028

SwissProt ID: P55197

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.