AF4 (MLLT2) polyclonal (C-term), anti-human
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In stock
SKU
AC-AP6189a
Catalog Number: AC-AP6189a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2247/2248
Applications: IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2247/2248
Applications: IHC-P
Datasheet
Request Information
Background:
MLLT2 is involved in acute leukemias through a chromosomal translocation t(4;11)(q21;q23) that involves mllt2 and mll/hrx. AF-4 (MLLT2), AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions. Stretches abundant in basic amino acids are also present in the three proteins. These results suggest that the different proteins fused to ALL-1 polypeptide(s) provide similar functional domains. AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus. The composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant negative mechanism in leukemogenesis.
Other Names:
AF4/FMR2 family member 1, ALL1-fused gene from chromosome 4 protein, Protein AF-4, Protein FEL, Proto-oncogene AF4, AFF1, AF4, FEL, MLLT2, PBM1
Target/Specificity:
This AF4 (MLLT2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1181~1210 amino acids from the C-terminal region of human MLLT2.
Antigen Region:
1181-1210
Antigen Type: Synthetic Peptide
Gene Name: AFF1
Gene ID: 4299
Primary Accession: P51825
NCBI Accession: NP_001160165.1;NP_005926.1
Other Accession: NP_005926
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
MLLT2 is involved in acute leukemias through a chromosomal translocation t(4;11)(q21;q23) that involves mllt2 and mll/hrx. AF-4 (MLLT2), AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions. Stretches abundant in basic amino acids are also present in the three proteins. These results suggest that the different proteins fused to ALL-1 polypeptide(s) provide similar functional domains. AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus. The composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant negative mechanism in leukemogenesis.
Other Names:
AF4/FMR2 family member 1, ALL1-fused gene from chromosome 4 protein, Protein AF-4, Protein FEL, Proto-oncogene AF4, AFF1, AF4, FEL, MLLT2, PBM1
Target/Specificity:
This AF4 (MLLT2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1181~1210 amino acids from the C-terminal region of human MLLT2.
Antigen Region:
1181-1210
Antigen Type: Synthetic Peptide
Gene Name: AFF1
Gene ID: 4299
Primary Accession: P51825
NCBI Accession: NP_001160165.1;NP_005926.1
Other Accession: NP_005926
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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