Aggrecan polyclonal, anti-human, rat

Background:
The large chondroitin sulfate proteoglycan, aggrecan, is the predominant proteoglycan present in cartilage. Aggrecan is a member of the chondroitin sulphate proteoglycan family, which also includes versican/PG-M, neurocan and brevican. Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification. Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network. Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage. Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage. Brevican is a brain proteoglycan of the aggrecan/versican/neurocan family. In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a full-length form a carboxy-terminal fragment and an amino-terminal fragment.

Alternative Name:
CSPCP, Chondroitin sulfate proteoglycan 1, ACAN, AGC1, CSPG1, MSK16, ACAN, AGC 1, AGC1, AGCAN, Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal, A0122), Aggrecan 1, Aggrecan core protein, Aggrecan proteoglycan, Aggrecan structural proteoglycan of cartilage, Aggrecan1, ATEGQV, Cartilage specific proteoglycan core protein, Chondroitin sulfate proteoglycan 1, Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal, A0122, Chondroitin sulfate proteoglycan core protein 1, CSPG 1, CSPG1, CSPGCP, JSCATE, Large aggregating proteoglycan, mcspg, mgsk16, MSK 16, MSK16, SEDK,

Application Dilution:
IHC:1:50-1:200

Specificity: Aggrecan polyclonal antibody detects endogenous levels of Aggrecan protein.

Immunogen:
recombinant protein

MW: 250/246/239 kDa

Swiss-Prot: P16112(Human) P07897(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.