AGRIN polyclonal antibody, anti-human, mouse, rat

Background:
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ)| as identified in mouse knock-out studies. The encoded protein contains several laminin G| Kazal type serine protease inhibitor| and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles| a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Neuroscience

Synonyms: Agrin

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year