AGT monoclonal (N-term), anti-human

Background:
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Other Names:
Angiotensinogen, Serpin A8, Angiotensin-1, Angiotensin 1-10, Angiotensin I, Ang I, Angiotensin-2, Angiotensin 1-8, Angiotensin II, Ang II, Angiotensin-3, Angiotensin 2-8, Angiotensin III, Ang III, Des-Asp[1]-angiotensin II, Angiotensin-4, Angiotensin 3-8, Angiotensin IV, Ang IV, Angiotensin 1-9, Angiotensin 1-7, Angiotensin 1-5, Angiotensin 1-4, AGT, SERPINA8

Target/Specificity:
This AGT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human AGT.

Antigen Region:
37-65

Antigen Type: Synthetic Peptide

Gene Name: AGT (HGNC:333)
Gene ID: 183
Primary Accession: P01019
NCBI Accession: NP_000020.1
Other Accession: NP_000020
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.