AGXT Polyclonal Antibody

Background:
Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene. This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1), also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
AGT, AGT1, Agxt, AGXT1, Alanine glyoxylate aminotransferase, Alanine glyoxylate aminotransferase3, Alanine--glyoxylate aminotransferase, EC 2.6.1.44, EC 2.6.1.51, Hepatic peroxisomal alanine glyoxylate aminotransferase, Hepatic peroxisomal alanine:glyoxylate aminotransferase, L alanine glyoxylate aminotransferase 1, MS773, PH1, Serine pyruvate aminotransferase, Serine--pyruvate aminotransferase, Serine--pyruvate aminotransferase, mitochondrial, Serine:pyruvate aminotransferase, SPAT, SPT, SPYA, TLH6

Immunogen: Synthetic peptide of human AGXT

Swissprot: P21549
Gene Accession: NP_000021

Calculated MW: 43 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-167057