AIF/AIFM1 Picoband™ (clone 2I5), anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO14853
Catalog Number: AC-ABO14853
Size: 100 µg
Isotype: Mouse
Applications: WB, IHC, IF, ICC, FC
Datasheet
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Size: 100 µg
Isotype: Mouse
Applications: WB, IHC, IF, ICC, FC
Datasheet
Request Information
Description: Anti-AIF/AIFM1 Antibody Picoband™ (monoclonal, 2I5) . Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.Protein Name: Apoptosis-inducing factor 1, mitochondrial
Protein Function:
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Other Names: Apoptosis-inducing factor 1, mitochondrial, 1.6.99.-, Programmed cell death protein 8, AIFM1 (HGNC:8768), AIF, PDCD8
Clone Name(s):
Clone: 2I5
Subcellular Localization: Mitochondrion intermembrane space. Mitochondrion inner membrane. Nucleus. Cytoplasm. Perinuclear region.
Tissue Specificity: Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers.
Gene ID: 9131
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human AIF, identical to the related mouse and rat sequences.
Calculated MW: 66901
Format: Lyophilized
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500 µg/ml.
Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Concentration (mg/ml): Adding 0.2 ml of distilled water will yield a concentration of 500 µg/ml.
Storage: Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Protein Function:
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Other Names: Apoptosis-inducing factor 1, mitochondrial, 1.6.99.-, Programmed cell death protein 8, AIFM1 (HGNC:8768), AIF, PDCD8
Clone Name(s):
Clone: 2I5
Subcellular Localization: Mitochondrion intermembrane space. Mitochondrion inner membrane. Nucleus. Cytoplasm. Perinuclear region.
Tissue Specificity: Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers.
Gene ID: 9131
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human AIF, identical to the related mouse and rat sequences.
Calculated MW: 66901
Format: Lyophilized
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500 µg/ml.
Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Concentration (mg/ml): Adding 0.2 ml of distilled water will yield a concentration of 500 µg/ml.
Storage: Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
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