AIF polyclonal, anti-human, mouse, rat

Protein Family: Enzymes

Pathway and Disease: Cell Growth and Death; Folding, sorting, and degradation; Nucleotide Metabolism

Description:
Apoptosis-inducing factor (AIF) is a mitochondrial protein that translocates to the nucleus upon induction of apoptosis. It has been demonstrated that AIF causes DNA fragmentation and chromatin condensation, and induces the release of cytochrome c and caspase-9 from mitochondria. Release of AIF from mitochondria was shown to be prevented by over-expression of Bcl-2, a protein involved in mitochondrial permeability.

Alternate Names: Apoptosis-inducing factor 1, Programmed cell death protein 8, AIFM1, AIF, PDCD8

Application Notes: E: 1:200-1:500; WB: 1:200-1:500; IHC: 1:500-1:1,000

Accession No.: O95831

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human AIF protein.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.