AIM2(clone3B10 ), anti-human

Decription:
AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16, MNDA, AIM2 and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.

Synonyms: Interferon-inducible Protein AIM2, Absent in Melanoma 2

Clone: 3B10

Isotype: Mouse IgG1

Immunogen: Human AIM2 (aa 1-186).

Reactivity: human

Specificity: Recognizes human AIM2.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Applications:
ICC: (1:200)
Western Blot: (1:1000)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1 mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)