AIM2 Polyclonal Antibody

Background:
Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-, AIM2 is thought to act as a tumor suppressor by repressing NFB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of -helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
Absent in melanoma 2, AIM 2, Aim2, AIM2, Interferon-inducible protein AIM2, OTTHUMP00000035296, PYHIN4

Immunogen: Recombinant protein of human AIM2

Swissprot: O14862
Gene Accession: BC010940

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.8 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-137970/sc-137971