AIRE polyclonal, anti-human, mouse

Background:
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

Synonyms: AIRE1, APECED, APS1, APSI, PGA1

Cellular Location: Cytoplasm Nucleus

Immunogen:
A synthetic peptide of human AIRE

Gene Symbol: AIRE

Gene ID: 326

Swiss prot: O43918

Calculated MW: 58kDa

Recommended dilution:
WB 1:500-2000, IF 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.