AIRE Polyclonal Antibody

Background:
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

Research Area: Cancer, Epigenetics and Nuclear Signaling, Immunology

Synonyms:
AIRE, AIRE1, APECED, APS1, APSI, PGA1

Immunogen: A synthetic peptide of human AIRE (NP_000374.1).

Swissprot: O43918
Gene ID: 326

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IF 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.