AK2 Polyclonal Antibody

Background:
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.

Research Area: Cancer, Cell Biology, Metabolism, Signal Transduction

Synonyms:
Adenylate kinase 2, adenylate kinase 2, mitochondrial, Adenylate kinase isoenzyme 2, ADK2, AK 2, ak2, ATP AMP transphosphorylase, ATP-AMP transphosphorylase 2, EC 2.7.4.3, KAD2, mitochondrial

Immunogen: Recombinant protein of human AK2

Swissprot: P54819
Gene Accession: BC009405

Calculated MW: 26 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-17621/sc-17623/sc-28786