AKAP5 antibody (clone 1A9), anti-human
€435.00
In stock
SKU
AC-AT1088a
Catalog Number: AC-AT1088a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB
Request Information AC-AT1088a">Request Information
Background:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
Other Names:
A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 79 kDa, AKAP 79, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, AKAP5, AKAP79
Antigen Type:
Recombinant Protein
Gene Name: AKAP5
Gene ID: 9495
NCBI Accession: NP_004848.3
Primary Accession: P24588
Other Accession: NM_004857
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
Other Names:
A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 79 kDa, AKAP 79, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, AKAP5, AKAP79
Antigen Type:
Recombinant Protein
Gene Name: AKAP5
Gene ID: 9495
NCBI Accession: NP_004848.3
Primary Accession: P24588
Other Accession: NM_004857
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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