AKIR1 polyclonal (C-term), anti-human
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In stock
SKU
AC-AP17755B
Catalog Number: AC-AP17755B
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB25247
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB25247
Applications: WB
Datasheet
Request Information
Background:
The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways. AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Other Names:
Akirin-1, AKIRIN1, C1orf108
Target/Specificity:
This AKIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-158 amino acids from the C-terminal region of human AKIR1.
Antigen Region:
131-158
Antigen Type: Synthetic Peptide
Gene Name: AKIRIN1 {ECO:0000303|PubMed:18066067, ECO:0000312|HGNC:HGNC:25744}
Gene ID: 79647
Primary Accession: Q9H9L7
NCBI Accession: NP_001129747.1;NP_078871.1
Other Accession: NP_078871.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways. AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Other Names:
Akirin-1, AKIRIN1, C1orf108
Target/Specificity:
This AKIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-158 amino acids from the C-terminal region of human AKIR1.
Antigen Region:
131-158
Antigen Type: Synthetic Peptide
Gene Name: AKIRIN1 {ECO:0000303|PubMed:18066067, ECO:0000312|HGNC:HGNC:25744}
Gene ID: 79647
Primary Accession: Q9H9L7
NCBI Accession: NP_001129747.1;NP_078871.1
Other Accession: NP_078871.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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