AKR1C1 Polyclonal Antibody

Background:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Research Area: Metabolism, Developmental Biology, Signal Transduction

Synonyms:
2-dihydrobenzene-1, 2-diol dehydrogenase, 20 alpha (3 alpha) hydroxysteroid dehydrogenase, 20 ALPHA HSD, 20 alpha hydroxysteroid dehydrogenase, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 20ALPHAHSD, 2ALPHAHSD, AK1C1, AK1C1, AKR1C1, Aldo keto reductase family 1 member C1, aldo-keto reductase C, Aldo-keto reductase family 1 member C1, Aldo-keto reductase family, 1 member 1, C9, Chlordecone reductase homolog, Chlordecone reductase homolog HAKRC, DD1, DD1/DD2, DDH, DDH1, Dihydrodiol dehydrogenase 1, Dihydrodiol dehydrogenase 1/2, dihydrodiol dehydrogenase 1, 20-alpha (3-alpha)-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase isoform DD1, Dihydrodiol dehydrogenase, type 1, H37, HAKRC, HBAB, Hepatic dihydrodiol dehydrogenase, High affinity hepatic bile acid-binding protein, High-affinity hepatic bile acid-binding protein, Indanol dehydrogenase, MBAB, MGC8954, Trans-1, Trans-1, 2 dihydrobenzene 1, 2 diol dehydrogenase, Type II 3 alpha hydroxysteroid dehydrogenase

Immunogen: Synthetic peptide of human AKR1C1

Swissprot: Q04828
Gene Accession: NP_001344

Calculated MW: 37 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.