AKR1C3 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.

Synonyms: DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS

Cellular Location: Cytoplasm

Immunogen:
Recombinant protein of human AKR1C3

Gene Symbol: AKR1C3

Gene ID: 8644

Swiss prot: P42330

Calculated MW: 37kDa

Recommended dilution:
WB 1:500-2000, IP 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.