AKT1 Polyclonal Antibody
€0.00
In stock
SKU
E-AB-30467
Catalog Number: E-AB-30467
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Applications: WB,IHC-p,ELISA
Datasheet, Questions? Contact us!
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Applications: WB,IHC-p,ELISA
Datasheet, Questions? Contact us!
Background:
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
Research Area: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction
Synonyms:
AKT 1, AKT, AKT1, AKT1, MGC99656, PKB, PKB-ALPHA, PRKBA, Protein Kinase B Alpha, Protein kinase B, Proto-oncogene c-Akt, RAC Alpha, RAC, RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha
Immunogen: Synthesized peptide derived from human Akt1 around the non-phosphorylation site of Thr450.
Swissprot: P31749
Calculated MW: 56 kDa
Observed MW: 55 kDa
Purification Method: Affinity purification
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Alternative for product with catalog number:
sc-7126/sc-1619/sc-1618/sc-55523/sc-8312
Citation(s):
https://pubmed.ncbi.nlm.nih.gov/31548177/
http://ijbms.mums.ac.ir/article_15512_0.html
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
Research Area: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction
Synonyms:
AKT 1, AKT, AKT1, AKT1, MGC99656, PKB, PKB-ALPHA, PRKBA, Protein Kinase B Alpha, Protein kinase B, Proto-oncogene c-Akt, RAC Alpha, RAC, RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha
Immunogen: Synthesized peptide derived from human Akt1 around the non-phosphorylation site of Thr450.
Swissprot: P31749
Calculated MW: 56 kDa
Observed MW: 55 kDa
Purification Method: Affinity purification
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Alternative for product with catalog number:
sc-7126/sc-1619/sc-1618/sc-55523/sc-8312
Citation(s):
https://pubmed.ncbi.nlm.nih.gov/31548177/
http://ijbms.mums.ac.ir/article_15512_0.html
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