AKT1 (Thr308) polyclonal, anti-human
€0.00
In stock
SKU
AC-AP10543A
Catalog Number: AC-AP10543A
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB27685
Applications: FC, WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB27685
Applications: FC, WB, IHC-P
Datasheet
Request Information
Background:
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
Other Names:
RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1, PKB, RAC
Target/Specificity:
This AKT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-309 amino acids from human AKT1.
Antigen Region:
282-309
Antigen Type: Synthetic Peptide
Gene Name: AKT1
Gene ID: 207
Primary Accession: P31749
NCBI Accession: NP_001014431.1;NP_001014432.1;NP_005154.2
Other Accession: Q98TY9; P47196; P31750; Q01314; NP_001014431.1; NP_001014432.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
Other Names:
RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1, PKB, RAC
Target/Specificity:
This AKT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-309 amino acids from human AKT1.
Antigen Region:
282-309
Antigen Type: Synthetic Peptide
Gene Name: AKT1
Gene ID: 207
Primary Accession: P31749
NCBI Accession: NP_001014431.1;NP_001014432.1;NP_005154.2
Other Accession: Q98TY9; P47196; P31750; Q01314; NP_001014431.1; NP_001014432.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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