AKT2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. This gene is mapped to 19q13.2. AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.

Description:
Rabbit IgG polyclonal antibody for RAC-beta serine/threonine-protein kinase (AKT2) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.

Synonyms:
AKT 2 antibody, Akt2 antibody, AKT2 protein antibody, AKT2_HUMAN antibody, HIHGHH antibody, Murine thymoma viral (v akt) homolog 2 antibody, murine thymoma viral (v-akt) homolog-2 antibody, PKB antibody, PKB beta antibody, PKBB antibody, PKBbeta antibody, PRKBB antibody, Protein kinase Akt 2 antibody, Protein kinase Akt-2 antibody, Protein kinase B beta antibody, RAC beta antibody, RAC beta serine threonine protein kinase antibody, RAC PK beta antibody, Rac protein kinase beta antibody, RAC-BETA antibody, RAC-beta serine/threonine-protein kinase antibody, RAC-PK-beta antibody, RACbeta antibody, V akt murine thymoma viral oncogene homolog 2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human AKT2(454-481aa DRYDSLGLLELDQRTHFPQFSYSASIRE), different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, IHC-F

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.