ALAS1 polyclonal, anti-human, mouse, rat

Background:
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms: ALAS, ALAS-H, ALAS3, ALASH, MIG4

Cellular Location: Mitochondrion matrix

Immunogen:
Recombinant protein of human ALAS1

Gene Symbol: ALAS1

Gene ID: 211

Swiss prot: P13196

Calculated MW: 71kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.