ALAS1 Polyclonal Antibody

Background:
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Cancer, Cardiovascular, Metabolism, Signal Transduction

Synonyms:
ALAS1, ALAS, ALAS-H, ALAS3, ALASH, MIG4

Immunogen: Recombinant fusion protein of human ALAS1 (NP_954635.1).

Swissprot: P13196
Gene ID: 211

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IF 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.