ALDH4A1 (clone ), anti-human, rat

Background:
Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH4A1 (aldehyde dehydrogenase 4 family member A1), also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), P5CDh, P5CDhL, P5CDhS or ALDH4, is a major enzyme involved in the proline degradation pathway. Localizing to the mitochondrial matrix, ALDH4A1 catalyzes the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate. A mutation in the gene encoding ALDH4A1 results in HPII (hyperprolinemia type II), a disease characterized by an excess of P5C and proline that is associated with mental retardation and seizures.

Alternative Name:
P5C dehydrogenase, ALDH4A1, ALDH4, P5CDH, AL4A1, aldehyde dehydrogenase 4, aldehyde dehydrogenase 4 family, member A1, Aldehyde dehydrogenase family 4 member A1, Aldehyde dehydrogenase, family 4, subfamily A, member 1, ALDH4, aldh4a1, Delta 1 pyrroline 5 carboxylate dehydrogenase, mitochondrial, Delta-1-pyrroline-5-carboxylate dehydrogenase, L-glutamate gamma-semialdehyde dehydrogenase, mitochondrial, mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase, P5C dehydrogenase, P5CD, P5CDh, P5CDhL, P5CDhS, Pyrroline-5-carboxylate dehydrogenase, RP11 128M10.1,

Application Dilution:
WB:1:1,000-1:2,000
IHC:1:50-1:200

Specificity: ALDH4A1 monoclonal antibody detects endogenous levels of ALDH4A1 protein.

Immunogen:
Synthetic peptide of C terminal human ALDH4A1.

MW: 62 kDa

Swiss-Prot: P30038(Human) P0C2X9(Rat)

Purification & Purity:
ProG affinity purified.

Format:
Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.