ALDH5A1 Polyclonal Antibody

Background:
This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene.

Research Area: Cancer, Metabolism, Neuroscience, Signal Transduction

Synonyms:
Aldedehyde dehydrogenase 5 family, Aldehyde dehydrogenase 5 family member A1, Aldehyde dehydrogenase 5A1, Aldehyde dehydrogenase family 5 member A1, ALDH5A 1, Aldh5a1, mitochondrial, Mitochondrial succinate semialdehyde dehydrogenase, NAD(+) dependent succinic semialdehyde dehydrogenase, NAD(+)-dependent succinic semialdehyde dehydrogenase, SSADH, SSDH, SSDH, Succinate semialdehyde dehydrogenase, Succinate-semialdehyde dehydrogenase

Immunogen: Synthetic peptide of human ALDH5A1

Swissprot: P51649
Gene Accession: NP_001071

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-70004/sc-70007/sc-130684