ALDOB antibody (clone 3B3), anti-human
€435.00
In stock
SKU
AC-AT1117a
Catalog Number: AC-AT1117a
Size: 100 µg
Isotype: mouse IgG2a kappa
Applications: E
Request Information AC-AT1117a">Request Information
Size: 100 µg
Isotype: mouse IgG2a kappa
Applications: E
Request Information AC-AT1117a">Request Information
Background:
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
Other Names:
Fructose-bisphosphate aldolase B, Liver-type aldolase, ALDOB, ALDB
Antigen Type:
Recombinant Protein
Gene Name: ALDOB {ECO:0000303|PubMed:15880727, ECO:0000312|HGNC:HGNC:417}
Gene ID: 229
NCBI Accession: NP_000026.2
Primary Accession: P05062
Other Accession: BC029399
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
Other Names:
Fructose-bisphosphate aldolase B, Liver-type aldolase, ALDOB, ALDB
Antigen Type:
Recombinant Protein
Gene Name: ALDOB {ECO:0000303|PubMed:15880727, ECO:0000312|HGNC:HGNC:417}
Gene ID: 229
NCBI Accession: NP_000026.2
Primary Accession: P05062
Other Accession: BC029399
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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