ALIX polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Programmed cell death 6-interacting protein is a protein that in humans is encoded by the PDCD6IP gene. This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Description:
Rabbit IgG polyclonal antibody for Programmed cell death 6-interacting protein (PDCD6IP) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
AIP1 antibody, ALG 2 interacting protein 1 antibody, ALG-2-interacting protein 1 antibody, ALG2 interacting protein X antibody, Alix antibody, Apoptosis linked gene 2 interacting protein X antibody, Dopamine receptor interacting protein 4 antibody, DRIP4 antibody, Hp95 antibody, KIAA1375 antibody, MGC17003 antibody, PDC6I_HUMAN antibody, PDCD6 interacting protein antibody, PDCD6-interacting protein antibody, PDCD6IP antibody, Programmed cell death 6 interacting protein antibody, Programmed cell death 6-interacting protein antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human ALIX recombinant protein (Position: A2-D330). Human ALIX shares 96.7% and 95.2% amino acid (aa) sequence identity with mouse and rat ALIX, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.